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DNADynamo can generate and display Global Multiple Sequence Alignments via Clustal Omega or Muscle, and also provides a
sophisticated alignment editor for correcting alignments and/or generating 'hand made' alignments
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Clustal Omega (and MUSCLE) are free 'academically developed' software that performs multiple sequence alignments on DNA and
Protein Sequences. You may also be familiar with ClustalX - A Graphical User Interface to the ClustalW software.
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DNADynamo can send your sequences to Clustal Omega or MUSCLE for alignment and display the Clustal Omega / MUSCLE output
files, conveniently integrating DNADynamo with Clustal Omega / MUSCLE.
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In DNADynamo's 'paged' display output, annotations are displayed and can be added to the sequence alignments, integrating BLASTs,
genbank annotations, user defined annotations and annotated clustal omega /muscle multiple alignments. Coloured and annotated
alignments can be printed to pdf for publication or further import and modification in dedicated illustration software.
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DNADynamo also provides a 'linear' alignment editor which supports mouse drag editing, making it easy to manually correct alignments
generated by clustal omega/muscle, or generate a complete 'hand made' alignment. When this editor is loaded with a DNA alignment,
you can display a correspondingly translated protein alignment, similar to the functionality provided by SE-AL software. Using these
functions it is possible to align the DNA sequences with respect to their protein translation, rather than just to the DNA sequence itself,
which some researchers believe generates a more meaningful alignment for input into phylogenetic tree software. With respect to this,
DNADynamo will also takes a bunch of DNA sequences, translate them, generate a protein alignment, and then re-assemble a DNA
alignment based on the protein alignment, which takes much of the work out of generating such translation respecting DNA alignments.
The alignments can be output as FASTA files or NEXUS files for input into phylogenetic software.
example alignment in
DNADynamos 'paged' display
which includes annotated
sequences. A linear alignment
editor that supports mouse
drag editing and simultaneous
dna->protein alignments is
also provided
DNADynamo
BlueTractorSoftware
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Windows
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Linux